Fillers, because the title so clearly conveys, restore misplaced quantity in just about any a part of your face, and a few components of your physique. There are not less than a couple dozen completely different hyaluronic acid fillers within the U.S., they usually have slight variations—in issues like viscosity—so injectors can select the proper one for the duty at hand, whether or not it’s smoothing tiny strains across the lips or constructing a sharper jawline. Rather a lot might be finished with this one molecule and the general public has totally embraced its line-smoothing, cheek sculpting skills: Fillers are the second hottest minimally-invasive beauty process, in accordance with a 2023 report by the American Society of Plastic Surgeons (neuromodulators like Botox are the primary).
Now, two new hyaluronic acid fillers are popping up on therapy menus: Evolysse Kind and Evolysse Easy. Permitted by the FDA in February, they’re beginning to roll out now. Each are authorized for treating the nasolabial folds, that are also called the snicker strains, with Kind being a bit thicker than Easy (extra on that quickly).
So… why are there new fillers on the block? And what do you want to find out about them?
For starters, whereas the 2 Evolysse injectables are created from hyaluronic acid, the best way they’re created is a bit completely different than their siblings. Should you’ll indulge us in a fast science lesson: Normally, hyaluronic acid is cross-linked (or bonded collectively so it stays collectively beneath the pores and skin) at excessive temperatures through the injectable formulation course of. The bonding course of itself can truly eat away on the hyaluronic acid, nevertheless, in order that’s the place the excessive temperatures are available—warmth speeds issues up so it takes much less time for the cross-linking agent (normally a chemical referred to as BDDE) to work and harm is minimized. The catch 22 right here is that warmth breaks down the hyaluronic acid a bit, too.
Evolysse takes thermal vitality out of the equation, with cross-linking carried out at close to freezing temperatures, says Rui Avelar, MD, chief medical officer and head of analysis and growth at Evolus. At chilly temperatures, Dr. Avelar and his group have been in a position to make use of much less BDDE to attain the specified stiffness of the hyaluronic acid gel, and the hyaluronic acid skilled much less fragmentation (i.e. breaking down into smaller items).
So, what does all that imply on your face? “If you put a conventional filler into the nasolabial folds, individuals usually begin to look a bit of puffy,” explains Michael Kaminer, MD, a board-certified dermatologist in Brookline, Massachusetts and affiliate medical professor of dermatology at Yale Medical College, who was an investigator through the medical trials for Evolysse. In these trials, he says, “at that three-month mark, individuals did not seem like the standard puffy patient that we see after we inject merchandise into the nasolabial fold. After we began to have our investigator conferences, individuals have been saying the identical factor like, ‘Hey, have you ever seen that the individuals are beginning to look a bit of bit extra pure? They’re getting an enchancment within the fold, however they are not trying puffy.’” It is because the hyaluronic acid in Evolysse is much less fragmented, says Dr. Kaminer, explaining that the extra you’ll be able to protect the pure construction of the hyaluronic acid in a filler, the extra natural its results shall be. (There’s no information evaluating the construction of hyaluronic acid in Evolysse on to that of the hyaluronic acid in different fillers.)
